The invention discloses a low-entropy mixed-combustion gas-charging explosion-exhaust engine, which comprises a gas compressor and an explosion-exhaust engine. A gas inlet of the gas compressor is a low-pressure oxygen-bearing gas inlet, a compressed gas outlet of the gas compressor is communicated with a gas charging hole of a combustion chamber of the explosion-exhaust engine, the pressure bearing capacity of the compressed gas outlet of the gas compressor is higher than 1MPa, and the gas compressor and the explosion-exhaust engine have no timing relation. The low-entropy mixed-combustion gas-charging explosion-exhaust engine is high-efficiency and low-emission and has the advantages of excellent load response and higher environmental protection and energy saving performances.