The invention discloses bisphenol 2 (m-amino p-hydroxy phenyl) ether hydrochloride such as 2,2-2(4-(3-amino-4-hydroxy phenoxy)phenyl) propane hydrochloride and a preparation method and an application of the bisphenol 2 (m-amino p-hydroxy phenyl) ether hydrochloride. The preparation method comprises the steps: nitrating p-hydroxy halogen benzene to obtain m-nitro p-hydroxy halogen benzene, protecting hydroxyl by benzyl, coupling the hydroxyl with a bisphenol agent to obtain ether, removing benzyl by means of hydrogenation and reduction and reducing nitryl into amino, and finally using hydrochloric acid to perform salifying to obtain the bisphenol 2 (m-amino p-hydroxy phenyl) ether hydrochloride. The compound provided by the invention is particularly suitable for the preparation of soluble polybenzoxazol, and the prepared polybenzoxazol has the characteristics of high strength and solubility in the common organic solvent, the defects of insolubility and difficulty in processing of the existing polybenzoxazol polymer are overcome, and the bisphenol 2 (m-amino p-hydroxy phenyl) ether hydrochloride can also be used for the preparation of polyamide and polyimide.