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CN102665687A 用于细胞刺激随后进行治疗性免疫的乙肝病毒抗原制剂 无效 - 撤回

用于细胞刺激随后进行治疗性免疫的乙肝病毒抗原制剂
摘要：
本发明涉及治疗性免疫的领域，特别涉及使用乙肝病毒(HBV)的抗原的新的制剂用于细胞刺激。所述制剂由HBV的悬浮液中沉淀的表面抗原(HBsAg)和核衣壳(HBcAg)构成。该制剂包含这些抗原的大小小于500nm和大于500nm的悬浮颗粒的混合物，其中所述大小的颗粒的比例分别是50％-50％和80％-20％。选择一定范围的大小的颗粒允许使数种细胞类型的刺激水平最大化。另外，描述了使用该制剂的细胞刺激方法和后续对患有慢性乙肝的患者的被动免疫，其是基于使用异源或自体细胞(树突细胞、B细胞和巨噬细胞)在体内或体外的最大化的刺激。以该制剂刺激的细胞被转移至慢性感染HBV的患者。
摘要（英）：

The present invention relates to the field of therapeutic immunization, specifically with the use of a novel hepatitis B virus (HBV) antigen formulation for cell stimulation. The formulation is formed by HBV surface antigen (HBsAg) and nucleocapsid antigen (HBcAg) precipitates in suspension. The formulation contains said antigens as precipitates in suspension as particles with sizes less than 500 nm and greater than 500 nm, in a mixture in which the proportion between the particles of the sizes mentioned is between 50% - 50% and 80% - 20%, respectively. The selection of a range of particle sizes allows the levels of stimulation of various cell types to be maximized. In addition, a description is given of a method for cell stimulation using said formulation and the subsequent passive immunization of patients with chronic hepatitis B, based on the maximum in vivo or in vitro stimulation of heterologous or autologous cells (dendritic cells, B cells and macrophages). The cells stimulated with this formulation are transferred to patients with a chronic HBV infection.

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