The invention discloses a penicillin borneol composition, which belongs to the technical field of preparation of medicaments. The penicillin borneol composition consists of penicillin and borneol in the mass ratio of 1:0.1-1:10, wherein the optimal mass ratio is 1:1. The composition can be prepared into various dosage forms such as tablets, capsules, particles, a sustained release agent, an injection and the like together with pharmaceutically-general auxiliary materials with the conventional medicament preparation method. The composition has a good inhibiting action on a plurality of medicament-resistant bacteria and a wide application prospect; and the order of magnitude of the MIC (Minimal Inhibitory Concentration) value is lowered, so that phenomenon of medicament resistance existing in the conventional antibiotics is greatly improved.