A live working manipulator for replacing an insulator string belongs to the technical field of power transmission and distribution projects and consists of four parts, namely a positioning mechanism, a clamping pin mechanism, a driving mechanism and a work condition display lamp part, wherein the manipulator carried out supporting operation by an insulating rod in a horizontal plane and is suspended by an insulating rope in a vertical surface for carrying out supporting operation. The positioning mechanism can be used for accurately gripping a bowl head and is displayed by a horizontal lamp and a reclining lamp to be in place. The clamping pin mechanism can be used for clamping a W-shaped pin for disassembly and assembly. The driving mechanism can be used for driving the clamping pin mechanism to realize the clamping, releasing, advancing and retracting of a clamp. The clamp is in place and clamps a clamp lamp and a limiting lamp for displaying. The live working manipulator can be used for replacing the insulator string without breaking off power and is used for maintaining high-voltage lines. The live working manipulator has the advantages of simple structure, reliability in work, high accuracy and time and labor saving.