The invention discloses an optically-active 2-hydroxyltetrathienopyridine derivative, a preparation method thereof and an application of the optically-active 2-hydroxyltetrathienopyridine derivative to pharmacy. As proved by a pharmacodynamic experiment result, the compound disclosed by the invention has a remarkable platelet aggregation suppressing function, and the platelet aggregation resisting functions of a part of compounds is better than that of clopidogrel. As proved by a pharmacokinetics experimental result, the compound provided by the invention can be effectively transformed into apharmacologically-active metabolite in vivo for playing a role in resisting platelet aggregation, and the bioavailability of the derivative is remarkably higher than that of clopidogrel. The compounddisclosed by the invention can be applied to preparation of a medicament for preventing or treating thrombus-related diseases. The invention further provides a preparation method of the compound.