The invention discloses a steel plate for a low-crack sensitivity pressure container with thickness being more than or equal to 80mm and a manufacture method of the steel plate. The steel plate comprises the chemical components in percentage by weight: 0.065-0.085 percent of C, 0.18-0.26 percent of Si, 1.40-1.60 percent of Mn, 0.20-0.40 percent of Ni, 0.15-0.25 percent of Cr, 0.20-0.25 percent of Mo, 0.035-0.045 percent of V, 0.030-0.045 percent of Nb, 0.025-0.03 percent of Ti, 0.020-0.07 percent of Alt, 0.015 percent of P, 0.005 percent of S and the balance of Fe. A metallographic structure of the steel plate comprises a tempered sorbite and a bainite. The manufacture method comprises the steps of: melting molten steel according to set components and casting into a steel ingot; heating and then carrying out two-stage rolling, namely, roughly rolling and precisely rolling; and rapidly cooling and then tempering for thermal treatment to obtain the steel plate which has excellent matching of strength, ductility, cold bending and impact resistance and meeting the requirement of steel for the pressure container.