The present invention discloses a Talnetant intermediate, a preparation method and applications thereof, wherein the intermediate has a structure represented by a formula I. With the intermediate compound represented by the formula I and for Talnetant preparation, Talnetant can be obtained through one-step hydrogenation. The preparation for the compound represented by the formula I has characteristics of simple production operation, easily available raw materials, low labor protection requirements, high yield and less by-product, and is suitable for industrial mass production.