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发明公开
CN102976955A 一种盐酸环苯扎林的精制方法 无效 - 撤回

  • 专利标题： 一种盐酸环苯扎林的精制方法
  • 专利标题（英）： Method for refining cyclobenzaprine hydrochloride
  • 申请号： CN201210541028.7
    申请日： 2012-12-14
  • 公开(公告)号： CN102976955A
    公开(公告)日： 2013-03-20
  • 发明人: 陈军 , 姚成
  • 申请人： 南京工业大学
  • 申请人地址： 江苏省南京市浦口区浦珠南路30号
  • 专利权人： 南京工业大学
  • 当前专利权人： 南京工业大学
  • 当前专利权人地址： 江苏省南京市浦口区浦珠南路30号
  • 主分类号： C07C211/32
  • IPC分类号： C07C211/32 ;  C07C209/84
一种盐酸环苯扎林的精制方法
摘要：
本发明公开一种盐酸环苯扎林的精制方法，属于医药领域。按每克盐酸环苯扎林粗品对应10～40毫升无水丙酮的量加入盐酸环苯扎林粗品和重结晶溶剂无水丙酮，加热回流基本溶清后，加入盐酸环苯扎林粗品质量5％～15％的活性炭，加热回流30分钟；放冷后再加入盐酸环苯扎林粗品质量1％～10％的硅胶进行吸附，搅拌回流20分钟，趁热过滤，滤液自然冷却至室温过夜；抽滤，40℃真空干燥，得白色盐酸环苯扎林精品，纯度达到99.6％以上。
摘要（英）：

The invention discloses a method for refining cyclobenzaprine hydrochloride, and belongs to the field of medicine. The method comprises the following steps of: adding a crude cyclobenzaprine hydrochloride product and anhydrous acetone serving as a re-crystallization solvent according to an amount that each gram of crude cyclobenzaprine hydrochloride product corresponds to 10 to 40 milliliters of anhydrous acetone, heating and refluxing till full dissolution, adding active carbon the mass of which is 5 to 15 percent of the mass of the crude cyclobenzaprine hydrochloride product, heating and refluxing for 30 minutes; cooling, adding silica gel the mass of which is 1 to 10 percent of the mass of the crude cyclobenzaprine hydrochloride product to carry out adsorption, stirring and refluxing for 20 minutes, filtering when the solution is hot, and naturally cooling the filtrate to room temperature over the night; and filtering, drying in vacuum at the temperature of 40 DEG C, and thus obtaining refined cyclobenzaprine hydrochloride of which the purity reaches more than 99.6 percent.

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