The invention discloses a 7-oxopyridinopyrimidine compound with a structure shown by formula (I) and a pharmaceutically acceptable salt or a stereoisomer or prodrug molecule thereof. The compound or pharmaceutically acceptable salt provided by the invention can effectively suppress the growth of multiple tumor cells and generate an inhibition effect on other proteases of the Her family of EGFR (epidermal growth factor receptor), can be used for preparing anti-tumor drugs and can overcome the drug resistance induced by the existing drugs gefitinib, erlotinib and the like.