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发明公开
CN103054877A 含泽泻醇A的组合物及其在医药上的应用 有权 转让

含泽泻醇A的组合物及其在医药上的应用
摘要：
本发明公开了一种含泽泻醇A的组合物及其在医药上的应用，所述含泽泻醇A的组合物，由如下重量比的组分组成：泽泻醇A∶泽泻醇A-23-乙酸酯∶泽泻醇A-24-乙酸酯＝1∶0.05～0.3∶0.05～0.5。本发明质量稳定、安全性高，长期使用所述的含泽泻醇A的组合物，比同等剂量下单一使用泽泻醇A或泽泻醇A-23-乙酸酯或泽泻醇A-24-乙酸酯具有更好的降血脂作用；体外肝细胞毒性试验结果显示，本发明对肝细胞的细胞毒性较同等剂量下单一使用泽泻醇A或泽泻醇A-23-乙酸酯或泽泻醇A-24-乙酸酯为弱。与泽泻醇A和泽泻醇A-24-乙酸酯组成组合物后，泽泻醇A-23-乙酸酯的稳定性明显增加，成药性增强。
摘要（英）：

The invention discloses a composition containing alisol A and an application of the composition containing alisol A on medicine, and the composition containing alisol A comprises the following ingredients by weight, alisol A: alisol A-23-acetate: alisol A-24-acetate is 1: 0.05-0.3: 0.05-0.5. The composition has the advantages of stable quality and high security, compared with single administration of alisol A or alisol A-23-acetate or alisol A-24-acetate, the composition containing alisol A with long-time administration has better hypolipemic effect by using same dosage with the alisol A or alisol A-23-acetate or alisol A-24-acetate, and in-vitro hepatotoxicity test results display that compared with single administration of alisol A or alisol A-23-acetate or alisol A-24-acetate with same dosage, the composition presents weak performance on cytotoxicity of hepatocyte. The alisol A-23-acetate combines with alisol A or alisol A-24-acetate to obtain the composition, the stability of alisol A-23-acetate is obviously increased, and the druggability is enhanced.

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