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发明授权
CN103097526B 赋予针对RAF和MEK抑制剂的抗性的MEK1突变 有权

赋予针对RAF和MEK抑制剂的抗性的MEK1突变
摘要：
提供了具有突变型MEK序列的核酸和蛋白质，和涉及鉴定对于用抗癌剂特别是RAF或MEK的抑制剂的治疗具有抗性的患者的方法。还提供了治疗和用于最佳化用于在MEK1序列中具有突变的患者的治疗的方法。
摘要（英）：

Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.

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