The invention relates to the field of a compound, and in particular relates to 1, 6-O-dicaffeoyl sorbitol ester as well as a derivative thereof. The general formula of the 1, 6-O-dicaffeoyl sorbitol ester and the derivative is shown in the specification. The prepared 1, 6-O-dicaffeoyl sorbitol ester has a strong effect for inhibiting the proliferation and differentiation of preadipocyte 3T3-L1 and eliminating DPPH free radicals. The invention provides application of the prepared 1, 6-O-dicaffeoyl sorbitol ester and the derivative thereof to producing drugs for treating the obesity and diseases caused by the obesity such as hyperlipidemia, hypertension, diabetes mellitus, fatty liver, coronary heart disease, sleep apnea syndrome and the like as well as the medicines and healthcare products related to the diseases, application to medicines or healthcare use for delaying senescence, improving the immunity and preventing the cancers, and application to an antioxidant and the like.