The invention relates to a preparation method of 2-amino-2-methyl-1-propyl alcohol. According to the preparation method, an alcoholic solution of alpha-amino isobutyric acid alkyl ester has hydrogenolyzing and reducing reaction with hydrogen in the presence of metal catalyst to generate 2-amino-2-methyl-1-propyl alcohol in one step. According to the process, the raw materials are cheap in price and easily available, and the reaction step is simple. The method hardly causes environmental pollution and is low in cost and high in yield; moreover, products are easy to purify. The preparation method of 2-amino-2-methyl-1-propyl alcoho is suitable for industrial production.