The invention discloses a designing method of an AC-16 asphalt mixture. The method which realizes the designing through adopting a vertical vibration process comprises the steps of selecting and testing raw materials, designing mineral aggregate gradation, determining an optimum asphalt-aggregate ratio, and examining performances. Results of the test verification show that the asphalt mixture obtained through the designing method has the advantages of good pavement performance, less consumption of asphalt, simple operation, and realization of saving 8-10% of asphalt.