The invention discloses a method and a device for controlling rear-end collision of vehicles in time of tire burst. The method includes: a rear vehicle detector detects, at certain time intervals, relative speed and relative distance L between a vehicle body and a rear vehicle as well as position coordinates of the rear vehicle corresponding to the vehicle body; a speed sensor detects the speed of the vehicle body, a transverse angular velocity sensor detects transverse angular velocity of the vehicle self, and a tire pressure sensor detects tire pressure; a controller sequentially calculates maximum deceleration that can be executed on different rear vehicles; according to maximum deceleration speed control, the controller controls the vehicle self to slow down within the maximum deceleration control speed through a vehicle power system and a brake producing device. By the method and the device, the vehicle self can be controlled to be braked to slow down in time of the tire burst according the speed of the same and the rear vehicle as well as the distance from the rear vehicle.