The invention discloses a preparation method of an all-wet nano NiFe2O4-NiO-Cu-Ni metal ceramic inert anode. The method comprises the following steps: by taking ferric oxide, nickel protoxide or nickel oxide, copper powder, nickel powder and the like as main raw materials, one or mixture of more of titanium powder, manganese dioxide, vanadium pentoxide, magnesium oxide and calcium oxide as a dopant, and one or mixture of more of water, absolute ethyl alcohol and polyvinylpyrrolidone (PVP) as a surfactant, preparing the NiFe2O4-NiO-Cu-Ni metal ceramic inert anode of which the grain size is 53nm and the compactness is greater than 99% by adopting a planet-type ball milling technology, a cold isostatic pressing (CIP) technology and an atmosphere sintering technology. The metal ceramic inert anode can replace the traditional carbon anode at present to be applied to an aluminium cell. The inert anode produced by the preparation method disclosed by the invention does not generate a toxic and harmful gas, and is friendly to environment and low in production cost.