The invention provides a preparation method of an ether ester compound. The method comprises the following steps: introducing a diether bond by reaction between cheap and accessible raw materials epoxy chloropropane and low-carbon alcohol, and esterifying with acyl chloride to finally obtain the target ether ester compound. The whole process is mild in reaction conditions and simple to operate. The method avoids using the virulent chemical iodomethane to perform O-alkylation reaction.