The invention relates to a chemical synthesis method of rasagiline and analogue thereof. The method for preparing rasagiline, provided by the invention, comprises the steps of enabling R-(-)-1-aminoindane (II) to directly react with alkane or arene propargyl sulfonate (III) and the like under an alkaline condition to obtain rasagiline (I), and correspondingly salifying according to the needs. The method provided by the invention has the advantages of few side reactions, high yield, short reaction time and mild reaction conditions, and impurities are very easy to remove in salifying, therefore, the product prepared by the method is high in purity and low in cost, and particularly avoids the impurity 2-Cl-AAI with genotoxicity, easily generated by adopting chloride ion-containing reagents such as 3-propargyl chloride and the like.