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发明公开
CN103936767A 一种制备化合物(1R,2S,6S,7S)-4,4-二甲基-9-苯甲基-3,5,8-三氧杂-9-氮杂三环[5.2.1.02.6]葵烷的方法 失效 - 权利终止

一种制备化合物(1R,2S,6S,7S)-4,4-二甲基-9-苯甲基-3,5,8-三氧杂-9-氮杂三环[5.2.1.02.6]葵烷的方法
摘要：
本发明公开了一种制备化合物(1R,2S,6S,7S)-4,4-二甲基-9-苯甲基-3,5,8-三氧杂-9-氮杂三环[5.2.1.02.6]葵烷的方法。所述方法包括步骤：（1）将化学结构如式1所示的化合物和锌粉在质子性溶剂中混合，得到化学结构如式2所示的化合物；（2）将化学结构如式2所示的化合物和苄基羟胺或其盐在无机碱存在的条件下在质子性溶剂中混合，得到化学结构如式3所示的化合物；和（3）将化学结构如式3所示的化合物在碱存在的条件下在氯苯中回流，得到化学结构如式4所示的化合物；所述无机碱选自碳酸钠、碳酸钾或碳酸氢钠；所述碱选自碳酸钾、碳酸钠、碳酸氢钠、吡啶或三乙胺。
摘要（英）：

The invention discloses a method for preparing a compound (1R,2S,6S,7S)-4,4-dimethyl-9-benzyl-3,5,8-trioxa-9-azatricyclo[5.2.1.0<2.6>]decane. The method comprises steps: (1) mixing a compound with the chemical structure shown as a formula 1 and zinc in a protic solvent, so as to obtain a compound with the chemical structure shown as a formula 2; (2) mixing the compound with the chemical structure shown as the formula 2 and benzylhydroxylamine or a salt thereof in a protic solvent in the presence of an inorganic base, so as to obtain a compound with the chemical structure shown as a formula 3, wherein the inorganic base is selected from sodium carbonate, potassium carbonate or sodium bicarbonate; and (3) refluxing the compound with the chemical structure shown as the formula 3 in chlorobenzene in the presence of a base, so as to obtain a compound with the chemical structure shown as a formula 4, wherein the base is selected from potassium carbonate, sodium carbonate, sodium bicarbonate, pyridine and triethylamine.

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