The invention discloses three formula granules for forming Shengmai powder and a preparation method thereof. According to the preparation method, ginseng, radix ophiopogonis and schisandra chinensis serving as raw medicinal materials are respectively subjected to extraction, concentration, drying, mixing, granulation and the like to prepare ginseng formula granules, radix ophiopogonis formula granules and schisandra chinensis formula granules, the three formula granules are compatible in a proportion, are stirred in boiling water to dissolve to obtain the Shengmai powder solution. Compared the Shengmai powder solution prepared by the method with traditional combined decoction of Shengmai powder, similarity of the two HPLC (high performance liquid chromatography) specific chromatograms is more than 0.9, and the content of 5-hydroxymethyl-2-furfural component is approximately same, and a remarkable technical progress is obtained compared with the widely believed viewpoint in the medical field that separated decoctions cannot generate novel substances generated in combined decoction; furthermore, the formula granules are convenient to carry, can quickly act, are safe and clean, flexible in prescription and dosage, and controllable in quality, and accord with the fast-paced city lifestyle of modern people.