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发明公开
CN104069488A 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 无效 - 驳回

多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法
摘要：
本发明提供了一种多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法，该共轭组合物是包括14种不同血清型的肺炎链球菌荚膜多糖和载体蛋白质共价连接形成的共轭组合物，其中，所述14种不同血清型包括1、4、5、6A、6B、7F、9V、14、18C、19A、19F、22F、23F和33F。该共轭组合物吸附效果及稳定性好，具有针对上述14种血清型的肺炎球菌侵袭的多重免疫原性和保护性能，优于已上市的低价次肺炎组合物，且免疫应答高于未结合的组合物。接种含有该共轭组合物的多价肺炎球菌荚膜多糖结合疫苗可以减少接种针次，简化免疫程序，同时可有效预防人及动物因上述14种血清型肺炎球菌所致的疾病，覆盖更加广泛，免疫效果更好。
摘要（英）：

The invention provides a multivalent pneumococcus capsular polysaccharide-protein conjugated composition and a preparation method thereof. The conjugated composition is formed by covalent linkage of multivalent pneumococcus capsular polysaccharides of 14 different serotypes and carrier protein, wherein the 14 serotypes include 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F. The conjugated composition has good adsorption effect and good stability, has multiple immunogenicity and protective performance against invasion of the pneumococcus of 14 serotypes, is superior to on-sale low-valent pneumonia compositions, and the immune response of the conjugated composition disclosed by the invention is higher than that of an uncombined composition. The inoculating injection frequency can be reduced by using the multivalent pneumococcus capsular polysaccharide conjugate vaccine containing the conjugated composition, the immune process can be simplified, and diseases of human and animals caused by the 14 serotypes of pneumococcal bacteria can be effectively prevented. The conjugated composition has wider coverage and better immune effect.

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