The invention provides a refining and chemical sewage desalting integrated treatment process and device. The process comprises the steps of adding CaO and Na2CO3 into refining and chemical sewage subjected to primary treatment to remove hardness, and regulating the pH value by using acid to obtain primary hardness removed sewage; filtering the primary hardness removed sewage by using a plurality of media and activated carbon to obtain pretreated sewage; carrying out ultrafiltration after mixing the pretreated sewage and sodium hypochlorite to obtain ultra-filtered sewage and filtered matters; carrying out ion exchange treatment after mixing the ultra-filtered sewage and a reducing agent to obtain deionized sewage; carrying out reverse osmosis treatment after mixing the deionized sewage and a scale inhibitor to obtain pure water and concentrated reverse osmosis water. The process also comprises the step of carrying out regeneration treatment on an ion exchange material for ion exchange treatment after removing concentrated organic matters in the concentrated reverse osmosis water through hydrogen peroxide and activated carbon oxidation treatment. The refining and chemical sewage desalting integrated treatment process can be used for increasing the comprehensive water yield and desalting rate of refining and chemical sewage desalting treatment, effectively controlling membrane pollution and realizing the recycle of the refining and chemical sewage.