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发明公开
CN104193719A 一种3,4-亚甲二氧基苯乙醇酸的制备方法 无效 - 驳回

一种3,4-亚甲二氧基苯乙醇酸的制备方法
摘要：
本发明涉及一种通过微波辐射合成洋茉莉醛中间体——3,4-亚甲二氧基苯乙醇酸的方法，以二氯乙酸甲酯为原料，与氢氧化钠或氢氧化钾的甲醇溶液在微波辐射下反应制得乙醛酸水溶液。然后用制得的乙醛酸水溶液与1,2-亚甲二氧基苯在微波辐射下反应最终制得3,4-亚甲二氧基苯乙醇酸，微波的使用，在反应时间大幅缩短的情况下，提高了3,4-亚甲二氧基苯乙醇酸产率。
摘要（英）：

The invention relates to a preparation method for a heliotropin midbody such as 3,4-methylene dioxy mandelic acid through microwave radiation. The preparation method comprises the following steps: taking methyl dichloroacetate as a raw material, and reacting with sodium hydroxide or methanol solution of potassium hydroxide under microwave radiation to obtain glyoxylic acid water solution; then reacting the obtained glyoxylic acid water solution with 1,2-methylenedioxybenxene under microwave radiation to prepare 3,4-methylene dioxy mandelic acid finally. Through the application of microwave, under the condition that the reaction time is greatly reduced, the yield of 3,4-methylene dioxy mandelic acid is improved.

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