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发明公开
CN104230954A 2,4-二氨基嘧啶类化合物及其医药用途 无效 - 驳回

2,4-二氨基嘧啶类化合物及其医药用途
摘要：
本发明涉及一类如下通式I表示的2,4-二氨基嘧啶类化合物、其药学上可接受的盐或药学上可接受的溶剂合物，其制备方法，包含该化合物的药物组合物，以及这些化合物在制备用于预防或治疗生物体内与渐变性淋巴瘤酶相关的细胞异常增殖、形态变化以及运动功能亢进等相关的疾病的药物以及与血管新生或癌转移相关的疾病的药物中的用途，尤其是在制备用于治疗或预防肿瘤生长与转移的药物中的用途。
摘要（英）：

The invention relates to a 2,4-diaminopyrimidine compounds shown as a general formula I, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation method thereof, a pharmaceutical composition comprising the compound, and applications of the compounds in drugs for preventing or treating diseases related to cell abnormal proliferation, morphologic changes and hyperkinesia which are related to anaplastic lymphoma kinase in biological bodies, and drugs related to angiogenesis and cancer metastasis, particularly drugs for treating or preventing tumor growth and metastasis. The general formula I is shown in the description.

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