The invention relates to the pharmaceutical technical field, and discloses a compound conjugated estrogen and medroxyprogesterone dual-layer tablet and a preparation method of the compound conjugated estrogen and medroxyprogesterone dual-layer tablet. The conjugated estrogen and medroxyprogesterone dual-layer tablet comprises a slow release layer and a quick release layer. The dual-layer tablet process is adopted for tablet pressing; the dual-speed release function is easy to achieve; convenience is brought to industrial production; meanwhile, the operative difficulty is greatly reduced; the production period is shortened; the production efficiency is improved; the medicine quality is better controlled. The compound conjugated estrogen and medroxyprogesterone dual-layer tablet is used for preparing slow release particles and quick release particles; the dual-layer tablet process is adopted for tablet pressing; the aims of slow release of conjugated estrogens in the tablet and quick release of medroxyprogesterone in the tablet are achieved; the conjugated estrogen and medroxyprogesterone dual-layer tablet prepared according to the preparation method has the dual-speed release function; after the conjugated estrogen and medroxyprogesterone dual-layer tablet is orally taken, the conjugated estrogens are slowly released to maintain the stable blood concentration, and the medroxyprogesterone is rapidly released to be beneficial to clinic treatment; the compound ingredient action lasts for 24 hours; the conjugated estrogen and medroxyprogesterone dual-layer tablet is taken one time each day; the conjugated estrogen and medroxyprogesterone dual-layer tablet is conveniently taken.