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CN104436158A Apelin-13在治疗糖尿病肾病中的应用 无效 - 撤回

Apelin-13在治疗糖尿病肾病中的应用
摘要：
本发明提供了一种用于治疗糖尿病肾病的药物，该药物是Apelin-13，它是由13个氨基酸组成的短肽。本发明揭示了Apelin-13能有效降低肾小球系膜细胞系HBZY-1和SV40以及Akita小鼠肾皮质细胞中HDAC1的表达水平从而抑制组蛋白ac-K，ac-H3K9和ac-H3K18的乙酰化，进而抑制由高糖引起的炎症因子MCP-1，ICAM-1和VCAM-1的水平的升高，最终抑制Akita小鼠由糖尿病引起的肾小球过度肥大和肾小球系膜的增大。本发明发现Apelin-13能够以降低组蛋白的乙酰化为靶点，能作为治疗糖尿病肾病的药物。
摘要（英）：

The invention provides a medicine for treatment of diabetic nephropathy, wherein the medicine is Apelin-13, and the Apelin-13 is a short peptide formed by 13 amino acids. The expression level of HDAC1 in glomerular mesangial cells HBZY-1 and SV40 and the HDAC1 in renal cortical cells of the mouse Akita can be reduced effectively by the Apelin-13 so that the acetylation of histones ac-K, ac-H3K9 and ac-H3K18 can be inhibited, further the increase of the level of inflammatory factors MCP-1, ICAM-1 and VCAM-1 due to hyperglycemia can be inhibited and finally the diabetes-induced glomerular hypertrophy and glomerular mesangium enlargement of the mouse Akita can be inhibited. Apelin-13 can be used a medicine for treating diabetic nephropathy by taking the reduction of the acetylation of histones as a target.

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