The invention discloses a large mine truck chassis and a large mine truck, and belongs to the technical field of vehicles. A first set of rear wheels of the chassis is hung on a truck frame through a first independent suspension. A second set of rear wheels of the chassis is hung on the truck frame through a second independent suspension, that is, the four rear wheels of the large mine truck chassis are divided into two sets, interference caused by intercheck between the first set of rear wheels and the second set of rear wheels is avoided, and conditions for achieving dynamic torque coordinating control and improving the steering performance of the whole truck are created; meanwhile, energy consumption generated when the truck makes a turn can be lowered, and unnecessary fuel consumption is reduced. In particular, under the situation that the turn is larger and the truck wheel adhesion coefficient is lower, slippage of inner-side wheels can be greatly reduced or avoided, and thus the operability and operation safety of the whole truck can be improved; besides, wear to tyres of the truck is lowered, and the operation cost is reduced. The chassis is adopted for the large mine truck, and the technical effects are achieved.