The invention discloses a goods storing and taking method and device for an intensive stereoscopic warehouse. Goods shelves of the warehouse are arranged in a row and column mode, the goods shelves are tightly arranged in the width direction, and passageways are reserved in the length direction of the goods shelves. Supporting beams used for containing pallets are arranged on the goods shelves, and goods are placed on the supporting beams through the pallets. The portions, below the supporting beams, of the goods shelves are provided with goods shelf tracks, and pallet runners operate on the goods shelf tracks. The goods shelf tracks are connected with main tracks through passageway tracks laid in the passageways, a goods transfer device is arranged at one end of each main track, and each goods transfer device is connected with a warehouse output and input conveying line. According to the goods storing and taking method and device for the intensive stereoscopic warehouse, the function that the goods on the pallets are put in and taken out of the warehouse automatically can be achieved, the pallet runners can work efficiently under intelligent scheduling of an existing information management system, namely, the pallet runners can move back and forth in the X direction and the Y direction and have the lifting function, the pallet runners can move to any unit goods station in the goods shelves of the stereoscopic warehouse through an elevator and the stereoscopic tracks, and therefore goods storing and taking can be conducted. Thus, maximum operating efficiency is achieved.