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发明授权
CN104447322B 单去甲氧基姜黄素水溶性衍生物及其制备方法和用途 有权

单去甲氧基姜黄素水溶性衍生物及其制备方法和用途
摘要：
本发明提供通式I所示的单去甲氧基姜黄素衍生物及其药学上可接受的盐，该化合物具有更好的水溶性，同时具有良好的抗肿瘤活性，对人胃癌细胞MGC‑803、人肝癌细胞Bel‑7402、人慢性白血病粒细胞K562和人胶质瘤U87具有不同程度的抑制作用，其半数抑制浓度（IC50）达到1μM水平，能够用于制备抗肿瘤药物。
摘要（英）：

The invention provides a water-soluble monodemethoxycurcumin derivative as shown in general formula I and a pharmaceutically acceptable salt thereof. The compound has higher water solubility as well as high antitumor activity, has a function of inhibiting human gastric carcinoma cells MGC-803, human hepatocellular carcinoma cells Bel-7402, human chronic leukemia granulocytes K562 and human glioma U87 to different extents, and can be used for preparing an antitumor medicament, and the IC50 (Inhibitory Concentration 50) reaches the level of 1 [mu]M.

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