The invention provides a soft and hard photoelectric composite board and a manufacturing method of the soft and hard photoelectric composite board. The soft and hard photoelectric composite board sequentially comprises a first electrical interconnection layer, a carrier layer, an optical wave guide layer and a second electrical interconnection layer from bottom to top, wherein the first electrical interconnection layer, the carrier layer, the optical wave guide layer and the second electrical interconnection layer are connected through prepregs. One end of the carrier layer and one end of the optical wave guide layer are separated from the first electrical interconnection layer, so that a flexible end is formed and used as a connection terminal capable of being inserted into a connector to be fixed. The soft and hard photoelectric composite board is provided with the flexible terminal and capable of being assembled together with the optical connector in a high-precision mode, the soft and hard photoelectric composite board can be packaged in a three-dimensional mode and has the advantages of being high in precision, low in coupling loss, easy to package, good in reliability and the like.