The invention discloses a fullerene cyclic peptide and a synthetic method thereof. The synthetic method comprises the following steps: dissolving a cyclic peptide with a protecting group in a DMF, adding butanedioic anhydride and N-methyl morpholine to react for 0.2-5 hours at room temperature, and carrying out extracting; dissolving extraction products and fullerene mono-addition pyrrolidine in a mixing solution of DCM and the DMF, adding DCC, HOBT and DMAP to react for 20-100 hours at room temperature, and performing column chromatography; dissolving column chromatography products in a mixing solution of TFA/DCM to react for 1-6 hours at room temperature, adding frozen diethyl ether, controlling the temperature of the mixed solution containing the frozen diethyl ether at -4 DEG C for staying overnight to separate out faint yellow matters, and drying the faint yellow matters to obtain the fullerene cyclic peptide. According to the fullerene cyclic peptide prepared by the synthetic method, the stability of polypeptide in vivo can be improved, and the antitumor activity is excellent; compared with corresponding linear peptide, the cyclic peptide has stronger receptor binding force and specificity, has the characteristics of highly-efficient cancer cell targeting property and highly efficient free group scavenging property, and is an excellent antioxidant.