The invention provides a pipe body for a 620MPa aluminum alloy drill pipe and a manufacturing method of the pipe body. The pipe body comprises the following components in percentage by weight: 7.5-8.5% of Zn, 1.7-2.3% of Mg, 1.7-2.6% of Cu, 0.1-0.3% of Fe, 0.1-0.3% of Ni, 0.1-0.2% of Zr, 0.01-0.02% of Ti, 0.2-0.3% of M, 0.1-0.2% of Cr, and the balance of Al. According to the pipe body, precipitation strengthening of the elements of Zn and Mg, atom cluster segregation zone strengthening of the element of Cu, solution strengthening and grain refinement of the element of Mn under the solution treatment temperature, and the added grain refinement of the compounded Zr and Ti are utilized, so that composite effects of solution strengthening, precipitation strengthening, grain refinement and the like are fully realized, and the strength, the hardness, the heat resistance of the pipe body for the aluminum alloy drill pipe are improved accordingly. The cost of the pipe body is low as the alloying constituent in the pipe body is simply designed.