The invention discloses a standing wave resonant piezoelectric mist spraying device and method. The standing wave resonant piezoelectric mist spraying device comprises a drive power source, a composite piezoelectric vibrator, a container, an inlet one-way valve, an outlet one-way valve, a swirl nozzle, a swirl valve element and an outlet one-way valve base, wherein a standing wave resonant cavity is formed in the container, penetrates through one end face of the container and is sealed through the composite piezoelectric vibrator; the electrode face of the composite piezoelectric vibrator is connected with the drive power source through a lead; the other end face of the container is provided with a fluid outlet; the outlet one-way valve is arranged at the fluid outlet; a fluid inlet is formed in the outer side wall of the container; the inlet one-way valve is installed at the fluid inlet; the swirl nozzle and the container are detachably connected; the swirl valve element and the outlet one-way valve base are arranged in the swirl nozzle; the swirl valve element is provided with multiple spiral swirl through grooves; a swirl chamber is formed in the swirl nozzle. The standing wave resonant piezoelectric mist spraying device solves the problems that a traditional atomizing device is complex in structure, large in size and high in manufacturing cost.