The present invention discloses a cefuroxime sodium powder preparation for injection. The preparation is prepared by the following steps: (1) preparing a sodium acetate solution by dissolving sodium acetate with a solvent for standby; (2) adding the solvent and water, and adding cefuroxime acid with stirring until complete dissolution; adding activated carbon, decolorizing, filtering, mixing with the solvent, washing the residue and a filter bottle, and filling a crystallization tank with the filtrate; (3) applying the particle process morphology and molecular assembly process crystal product molecular assembly and shape-state optimization technology by Hebei Huamin Pharmaceutical Co. Ltd. of North China Pharmaceutical Co. Ltd., controlling the temperature and stirring speed, and dropwise adding sodium acetate solution; and adding a solvent agent according to the flow rate; (4) carrying out pumping filtration, washing, vacuum drying, weighing, and packing; and 5) packing the preparations in different specifications to obtain the cefuroxime sodium for injection. The cefuroxime sodium powder prepared by the method has the advantages of excellent hydrodynamic performance, perfect crystal shape, uniform particle size distribution, and greatly improved color grade, clarification, purity and stability.