The invention discloses an LED lighting circuit with a double-power-supply drive. The LED lighting circuit comprises two power supply modules, two power supply monitoring modules, two LED lamp groups, two constant current control modules and a bidirectional control switch, wherein the cathode output end of each power supply module is connected with the input end of the corresponding power supply monitoring module and the cathode of the corresponding LED lamp group; the anode output end of each power supply module is connected with the output end of the corresponding power supply monitoring module, and is further connected with a signal input end of the bidirectional control switch through a corresponding diode; the anodes of the two LED lamp groups respectively pass through the corresponding constant current control modules and are subsequently connected with the signal input end of the bidirectional control switch; monitoring signal output ends of the two power supply monitoring modules are respectively and correspondingly connected with two monitoring signal input ends of the bidirectional control switch. Due to the adoption of the two groups of power supply double-drive circuits, the service life of an LED lighting device is greatly prolonged by controlling the bidirectional control switch. The LED lighting circuit is applicable to the field with LED beads for lighting in the prior art.