The present invention belongs to the field of pharmaceutical and chemical industry, and relates to a nucleotide phosphonate compound, a pharmaceutical composition, a preparation method and uses thereof, particularly to a non-cyclic nucleotide phosphonate compound represented by a general formula, a pharmaceutically acceptable inorganic or organic salt, and a preparation method thereof, and a composition containing the compound represented by the general formula I. The compound of the present invention can be used as the active substance for treatment and/or prevention of viral infection diseases. The formula I is defined in the instruction.