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发明公开
CN104906586A 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用 无效 - 驳回

一种盐酸伊立替康复合磷脂组合物、制备方法及其应用
摘要：
本发明公开了一种盐酸伊立替康复合磷脂组合物、制备方法及其在制备治疗肿瘤或耐药性肿瘤的药物中的用途。所述复合磷脂组合物包含盐酸伊立替康、复合磷脂、胆固醇、长循环膜材、表面活性剂、缓冲介质。该组合物主要解决了现有脂质制剂体内外稳定性差、药物易泄漏等问题，能大大提高脂质制剂的稳定性及盐酸伊立替康的抗肿瘤作用，并可克服肿瘤的多药耐药。
摘要（英）：

The present invention discloses an irinotecan hydrochloride composite phospholipid composition, a preparation method and applications of the irinotecan hydrochloride composite phospholipid composition in preparation of drugs for treatment of tumors or drug-resistant tumors, wherein the composite phospholipid composition contains irinotecan hydrochloride, a composite phospholipid, cholesterol, a long cycle membrane material, a surfactant and a buffered media. According to the present invention, with the composition, the problems of poor stability in vitro and in vivo, easy drug leakage and the like of the existing lipid preparations are mainly solved, the stability of the lipid preparation and the anti-tumor effect of the irinotecan hydrochloride can be substantially improved, and the multidrug resistance of the tumor can be overcome.

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