The invention relates to a quinoline derivative, particularly a quinoline derivative comprising trimethylamine and a preparation method and use of the quinoline derivative. The molecular structural formula of the derivative is shown the description. The quinoline derivative comprising trimethylamine provided by the invention has a good effect in detecting cadmium in cells and the preparation method is simple and feasible and easy to operate; the quinoline derivative serving as a fluorescent probe can be used for quantitatively detecting concentration of cadmium ions.