Gain offset and voltage offset compensation for a controllable gain element of a circuit is effected in response to a gain offset value and voltage offset value. A current operating condition of the circuit is sensed and compared to a nominal operating condition. If the current operating condition is outside the nominal operating condition by more than a threshold, a calibration operation to set the gain and voltage offset values is performed. The gain offset value is selected as a function of the sensed current operating condition. With respect to the voltage offset, differential input terminals of the controllable gain element are shunted and the output is measured. The measured output value of the controllable gain element is applied as the voltage offset value. The operating conditions at issue may be one or more of supply voltage and temperature.