The invention discloses a search-and-rescue method and system based on integration measure random meet uncertainty. The method comprises the following steps: 1, determining a path L along which a lost person D gets lost, and determining a position point where the lost person D is located on the path L finally; 2, measuring the length I of the path L, and measuring a position point where a searcher C is located on the path L; 3, calculating a probability density function that the searcher C and the lost person D are distributed on the path L, and deriving out a meet event Emeet; 4, calculating out the meet probability p (Emeet) according to the probability density function and the meet event Emeet; 5, deriving out the probability p (Emeet xk) of 'an event that the searcher C located at a point xk can meet the lost person D' according to the meet probability p (Emeet); 6, conducting the search and rescue in a mode that the searcher C moves to a position adjacent to a point xm where the lost person D can be found to the maximum probability.