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发明公开
CN105198682A 一种取代联苯的制备方法 有权

一种取代联苯的制备方法
摘要：
本发明公开了一种取代联苯的制备方法，其包括下述步骤：在无水条件下，在溶剂中，在Ni盐和ZnX3X4的存在下，将化合物2和化合物3进行偶联反应，得到取代联苯即可；所述的Ni盐为NiX5X6(PPh3)2、NiX7X8(dppp)、NiX9X10(dppf)、NiX11X12(dppe)和乙酰丙酮镍中的一种或多种；所述的偶联反应的温度为0～30℃；在所述的化合物2与所述的化合物3的混合之前，所述的ZnX3X4与所述的化合物3混合。该方法反应条件温和、工艺简单、操作安全、对设备要求低、后处理简单、对环境污染小、易于工业化生产、卤化锌用量低、成本低、收率高、产品纯度高。
摘要（英）：

The invention discloses a preparation method of substituted biphenyl. The preparation method includes the steps that under the anhydrous condition, a compound 2 and a compound 3 are subjected to a coupled reaction in solvent in the presence of Ni salt and ZnX3X4, and then substituted biphenyl is obtained, wherein Ni salt is one or more of NiX5X6(PPh3)2, NiX7X8(dppp), NiX9X10(dppf), NiX11X12(dppe) and acetylacetone nickel, the temperature of the coupled reaction is 0-30 DEG C, and ZnX3X4 is mixed with the compound 3 before the compound 2 is mixed with the compound 3. According to the method, reaction conditions are mild, the process is simple, operation is safe, requirements for equipment are low, aftertreatment is simple, pollution to the environment is small, industrial production is easy, the usage quantity of zinc halides is small, the cost is low, the yield is high, and the product purity is high.

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