The invention provides a Meisuoshuli oral suspension and a preparation method thereof. The Meisuoshuli oral suspension comprises Meisuoshuli and pharmaceutically acceptable auxiliary materials. The Meisuoshuli oral suspension has the advantages of stable quality, small viscosity, no settlement or agglomeration phenomenon after long-time disposing, rapid dispersing uniformity after shaking, good mouthfeel, and good patient compliance, and can meet demands of swallowing dysfunction patients, old people and children of convenient administration of Meisuoshuli.