The invention discloses a variable-wheel-center four-wheeler capable of being automatically locked. The variable-wheel-center four-wheeler comprises four wheels installed on a wheeler body through wheel rotating shafts, each wheel comprises a wheel body and a wheel center adjusting device on the wheel body, each wheel center adjusting device comprises a lead screw arranged in radial direction through a wheel center, a nut and a lead screw transmission mechanism, the nuts and the lead screw transmission mechanisms are meshed with the lead screws, the wheel rotating shafts are installed on the nuts which are installed on the wheel rotating shafts, each lead screw transmission mechanism comprises a wheel center adjusting motor, a gear transmission pair and a worm and gear transmission gear, each gear transmission pair is composed of a wheel center adjusting driving gear and a wheel center adjusting driven gear, each worm and gear transmission gear is composed of a worm gear and a worm, the wheel center adjusting driving gears are installed on output shafts of the wheel center adjusting motors, the wheel center adjusting driven gears are installed on the worms, and the worm gears are installed on the lead screws; a control device is arranged to automatically adjust the eccentric distance of the wheel centers. Movement transmission can be achieved, adjustment of the eccentric distance of the wheel centers can be completed, self-locking of own transmission can be guaranteed, and adjusting is more reliable.