The invention discloses a swab box provided with a dropping liquid dipping and swab outlet mechanism, and the problems in a current sealing device that expected functions can hardly be realized; the sealing device is disposable; the cost is high; and waste is caused are solved. The swab box provided with the dropping liquid dipping and swab outlet mechanism consists of a body and a swab storage box; the body comprises a body shell; the swab storage box comprises a swab storage box shell, a No.1 rubber plug and a No.2 rubber plug; the swab storage box and the body are arranged left and right; one end of the swab storage box is in contact with one end of the body shell; a swab storage box swab outlet in the swab storage box shell is aligned with a body swab inlet in the body shell; the No.1 rubber plug is inserted into a No.1 connection port in the body shell; the No.2 rubber plug is inserted into a No.2 connection port in the body shell; the No.1 rubber plug is connected with the corresponding side wall of the swab storage box shell through an adhesive; the No.2 rubber plug is connected with the corresponding side wall of the swab storage box shell through the adhesive; and the body is integrally connected with the swab storage box.