The invention provides an anti-tumor compound, and the structural formula of the anti-tumor compound is as followed (please see the structural formula in the description). The invention further provides a preparation method of the compound, and the method has the advantages of being simple in step and high in yield. According to the compound, proliferation of tumor cells can be inhibited through targeted thyroid hormone receptor interaction 13 genes or proteins, the purpose of preventing and treating tumors is achieved, and experiments prove that the compound can be used for preventing and treating the tumors such as multiple myeloma and lymphoma. Due to the fact that the compound is a small-molecule targeted compound, compared with an untargeted drug, the compound is better in effect and fewer in side effect and has the good application prospect in the cancer field.