The invention discloses a preparation method of 2-(2--fluoro-4-biphenylyl) propionic acid, and belongs to the technical fields of chemical synthesis and medicines. A zinc reagent is prepared from trimethyl-chlorosilane as a zinc powder activating agent; with 4-bromo-2-fluoro biphenyl as a raw material, 2-(2-fluoro-4-biphenyl) ethyl propionate is obtained by reaction under the action of the zinc reagent and a catalyst-ligand; and the 2-(2-fluoro-4-biphenylyl) propionic acid is obtained through hydrolysis. The method is simple in process, simple and convenient to operate and short in reaction time; the product is high in yield, few in impurity, simple in post-treatment, high in equipment utilization rate and suitable for large-scale industrial production and application. Particularly, by a metal nickel-ligand catalyst system, the catalyst is high in activity and low in dosage; and the yield of the product can be effectively improved.