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发明公开
CN105669368A 高纯低色度吉非罗齐的制备方法 有权

高纯低色度吉非罗齐的制备方法
摘要：
本发明公开了一种高纯、低色度吉非罗齐的制备方法，包括步骤1)、的制备吉非异丁酯粗品；还包括以下步骤：2)、在吉非异丁酯粗品中加入碱液Ⅱ，直至所得体系的pH值为10.0～12，然后减压精馏，得吉非罗齐异丁酯；3)、吉非罗齐异丁酯经回流碱水解、调酸，得吉非罗齐粗品；4)、粗品精制：在吉非罗齐粗品中加入醇水溶液，升温至回流并保温0.5～1小时，冷却降温至0～5℃并保温搅拌1.5～2.5小时，过滤，所得的滤饼烘干，得高纯度、低色度的吉非罗齐。
摘要（英）：

The invention discloses a high-purity low-chroma gemfibrozil preparation method. The method comprises 1, preparing a gemfibrozil isobutyl ester crude product and can also comprises 2, adding an alkali liquor II in the gemfibrozil isobutyl ester crude product until the system pH is in a range of 10.0-12 and carrying out reduced pressure rectification to obtain gemfibrozil isobutyl ester, 3, carrying out reflux alkaline hydrolysis on the gemfibrozil isobutyl ester and carrying out acid adjustment to obtain a gemfibrozil crude product, and 4, refining the gemfibrozil crude product through adding an alcohol-water solution into the gemfibrozil crude product, carrying out heating reflux, carrying out heat preservation for 0.5-1h, carrying out cooling to a temperature of 0-5 DEG C, carrying out thermal insulation stirring for 1.5-2.5h, carrying out filtration to obtain filter cake and drying the filter cake to obtain high-purity low-chroma gemfibrozil.

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