The invention discloses an industrial method for removing harmful substances, especially sudan in capsanthin. Nitrile solvent is added to capsanthin, heating and stirring are conducted to form mixed liquid, a uniform system is formed by means of a colloid mill, temperature is reduced after reaction lasts for a period of time, centrifugal separation or standing separation is conducted to obtain a solvent layer and a capsanthin layer, and the capsanthin layer is concentrated to remove a small amount of solvent inside, so that a capsanthin product without sudan is obtained. The adopted solvent can well dissolve sudan but can not well dissolve capsanthin, the source is wide, sufficient mixing of the solvent and capsanthin is achieved through the colloid mill, the sudan removing effect is good, processing capacity is high, capsanthin color value recovery rate is 95% or more, and industrial production can be achieved.