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发明公开
CN105705508A 非环核苷磷酸酯类衍生物及其制备方法与在医学上的应用 失效 - 权利终止

非环核苷磷酸酯类衍生物及其制备方法与在医学上的应用
摘要：
本发明提供了一种非环核苷磷酸酯类衍生物及其制备方法与在医学上的应用，所述非环核苷磷酸酯类衍生物为通式(I)所示化合物、其立体异构体或药学上可接受的盐：R1为H或甲基；R2为H、C1-10为烷基、-(CH2-CH2-O)n-H或-(CH2-CH2-O)n-C1-10烷基，所述烷基任选进一步被0至5个R2a取代；R3为C1-10烷基、-(CH2-CH2-O)n-H或-(CH2-CH2-O)n-C1-10烷基，所述烷基任选进一步被0至5个R3a取代；R2a和R3a各自独立为H、F、Cl、Br、I、羟基、巯基、氨基、氰基、羧基、C1-4烷基或C3-6环烷基；n为1～10。
摘要（英）：

Provided in the present invention are an acyclic nucleoside phosphonate derivative and a preparation method and use thereof in medical science, and the acyclic nucleoside phosphonate derivative is a compound as shown by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof: R1 is H or methyl; R2 is H, C1-10 alkyl, -(CH2-CH2-O)n-H or -(CH2-CH2-O)n-C1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R2as; R3 is C1-10 alkyl, -(CH2-CH2-O)n-H or -(CH2-CH2-O)n-C1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R3as; each of R2a and R3a are independently H, F, Cl, Br, I, hydroxyl, sulfydryl, amino, cyano, carboxyl, C1-4 alkyl or C3-6 cycloalkyl; and n is 1-10.

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